MXRA8

Across TCGA pan-cancer cohorts, MXRA8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MXRA8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MXRA8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MXRA8 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where MXRA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MXRA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+1.538	<.001	11	view →
KIRC	All	III,IV	+1.175	<.001	11	view →
THCA	All	IV	+2.665	<.001	10	view →
KICH	Female	All	−2.751	<.001	8	view →
UCEC	All	All	−1.890	<.001	6	view →
LUAD	All	II,III,IV	+0.783	.003	6	view →
LIHC	Female	All	+1.152	.004	5	view →
COAD	All	II,III,IV	+0.596	.005	5	view →
BLCA	Male	All	−1.386	<.001	4	view →
CHOL	Female	All	+2.443	<.001	3	view →
STAD	Male	II,III,IV	+1.466	.001	3	view →
BRCA	All	All	−0.285	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MXRA8–HNSC

Open the HNSC breakdown →