MXRA5

Across TCGA patient cohorts, MXRA5 mutation is significantly associated with the total protein of many other genes, with 114 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MXRA5-associated genes across cancer lineages are PCNA, 14-3-3_beta, and Cyclin-B1. Each is linked with MXRA5 in more than 6 cancer types. Because this analysis shows association rather than direction, both MXRA5-to-partner and partner-to-MXRA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MXRA5-low versus MXRA5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXRA5→partner) and Y-score (partner→MXRA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.286	+3.584	.004	.002	3	7
UCEC	14-3-3_beta →	-0.092	-1.920	<.001	<.001	3	5
LUAD	Cyclin-B1 →	+0.598	+1.959	<.001	<.001	3	5
STAD	c-Kit →	-0.284	-2.000	.009	.025	3	5
UCEC	eEF2 →	+0.211	+1.000	.014	.037	3	4
LUAD	FoxM1 →	+0.251	+4.121	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

PCNA by MXRA5 expression — STAD

Explore this box plot interactively →