MXRA5

Across TCGA pan-cancer cohorts, MXRA5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MXRA5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MXRA5 RNA is repressed in tumor relative to normal tissue. In most cancer types MXRA5 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, HNSC, and LUAD are the cancer types where MXRA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MXRA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−3.098	<.001	11	view →
HNSC	Female	III,IV	+2.513	<.001	11	view →
LUAD	Male	II,III,IV	+2.630	<.001	9	view →
KIRC	Female	All	−1.433	<.001	9	view →
STAD	Male	II,III,IV	+2.345	<.001	8	view →
BRCA	All	III,IV	+1.385	<.001	8	view →
LUSC	Female	All	+2.485	<.001	7	view →
LIHC	Male	All	−0.853	<.001	5	view →
COAD	All	II,III,IV	+0.771	.002	5	view →
READ	Male	All	+2.453	.015	2	view →
KIRP	Male	All	−0.889	.016	2	view →
THCA	All	All	+0.438	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MXRA5–KICH

Open the KICH breakdown →