MXRA5

Across TCGA pan-cancer cohorts, MXRA5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MXRA5 data layer compared with 15 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MXRA5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MXRA5 expression acts as an unfavorable survival marker, although some lineages such as LAML and UCS show a favorable association.

UVM, LGG, and ACC are the cancer types where MXRA5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	III,IV	0.246	0.836	.003	41	view →
LGG	OS	Median	All	0.749	0.876	<.001	39	view →
ACC	DFS	Tertile	All	0.248	0.634	<.001	30	view →
LAML	DFS	Tertile	All	0.540	0.291	.001	30	view →
CESC	DFS	Tertile	All	0.650	0.811	.003	26	view →
UCS	DFS	Median	II,III,IV	0.531	0.209	.004	18	view →
DLBC	DFS	Tertile	III,IV	1.000	0.387	.013	17	view →
BLCA	OS	Tertile	II,III,IV	0.319	0.482	.010	16	view →
LIHC	DFS	Tertile	III,IV	0.669	0.234	.003	14	view →
CHOL	DFS	Median	All	0.599	0.257	.027	13	view →
GBM	OS	Tertile	All	0.300	0.477	.008	10	view →
COAD	OS	Tertile	IV	0.895	0.332	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MXRA5–UVM (OS)

Open the UVM breakdown →