Q-omics provides the consensus-scored MUPP profile across patient tissues and cancer cell-line models. MUPP expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in LAML. Among the 18 cancer types available for tumor–normal comparison, MUPP is differentially expressed in 7, with the highest sampling consensus in KIRC. Additionally, MUPP RNA expression shows 11,375 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LAML, KIRC, and THYM as cancer lineages where MUPP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MUPP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MUPP survival associations across molecular data types. MUPP RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MUPP RNA expression–survival associations across cancer types. High MUPP expression shows unfavorable associations in COAD, UVM and SKCM, but favorable associations in LAML, GBM and LGG. The LAML Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LAML as the clearest survival context for MUPP RNA expression.
This table summarizes MUPP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for MUPP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MUPP shows lower tumor expression in LUSC, UCEC, LUAD, KICH and STAD and higher tumor expression in KIRC. The KIRC box plot shows higher MUPP RNA expression in tumor versus normal tissue (log2 FC = +0.091, t-test p < 0.001).
This table shows molecular features associated with MUPP in patient tissues and cancer cell lines. In patient samples, MUPP shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
