MUPP

Across TCGA pan-cancer cohorts, MUPP RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated MUPP data layer.

The strongest signal is observed in acute myeloid leukemia (LAML), where higher MUPP RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MUPP expression acts as an unfavorable survival marker, although some lineages such as LAML and GBM show a favorable association.

LAML, COAD, and GBM are the cancer types where MUPP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LAML	DFS	Median	All	0.612	0.225	<.001	36	view →
COAD	OS	Tertile	II,III,IV	0.237	0.582	.001	33	view →
GBM	DFS	Quartile	All	0.385	0.186	.002	31	view →
UVM	OS	Tertile	All	0.336	0.736	.006	30	view →
LGG	OS	Median	All	0.931	0.858	<.001	25	view →
SKCM	DFS	Tertile	IV	0.045	0.471	.016	21	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
PRAD	OS	Tertile	All	0.965	0.998	<.001	18	view →
KICH	DFS	Tertile	III,IV	0.025	0.773	<.001	18	view →
KIRP	DFS	Tertile	All	0.335	0.676	.006	18	view →
UCEC	DFS	Tertile	All	0.445	0.668	.015	18	view →
KIRC	DFS	Tertile	III,IV	0.622	0.324	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

MUPP–LAML (DFS)

Open the LAML breakdown →