MUC20-OT1

Across TCGA patient cohorts, MUC20-OT1 mutation is significantly associated with the RNA expression of many other genes, with 1,051 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC20-OT1-associated genes across cancer lineages are CYCSP2, RN7SL369P, and H2AB2. Each is linked with MUC20-OT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC20-OT1-to-partner and partner-to-MUC20-OT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP2 grouped by MUC20-OT1-low versus MUC20-OT1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC20-OT1→partner) and Y-score (partner→MUC20-OT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CYCSP2 →	+0.141	+4.423	.007	.001	3	2
UCEC	RN7SL369P →	+0.157	+2.384	<.001	.002	3	2
BRCA	H2AB2 →	+0.049	+7.057	<.001	.009	3	1
CESC	SLC25A15P2 →	+0.122	+4.306	<.001	.001	3	1
CESC	LINC02877 →	+0.295	+3.687	.002	.007	3	1
CESC	SNORD126 →	+0.363	+3.411	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,051 associations by consensus.

CYCSP2 by MUC20-OT1 expression — CESC

Explore this box plot interactively →