MUC20-OT1

Across TCGA pan-cancer cohorts, MUC20-OT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MUC20-OT1 data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MUC20-OT1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MUC20-OT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, ACC, and LIHC are the cancer types where MUC20-OT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.860	0.710	.001	67	view →
ACC	OS	Tertile	All	0.252	0.891	<.001	43	view →
LIHC	DFS	Quartile	All	0.416	0.615	.005	42	view →
BLCA	OS	Tertile	All	0.689	0.532	.003	39	view →
UCEC	DFS	Tertile	All	0.510	0.707	.002	36	view →
SKCM	DFS	Quartile	All	0.318	0.141	.001	27	view →
LUAD	DFS	Median	IV	0.306	0.764	.010	20	view →
READ	OS	Quartile	II,III,IV	0.869	0.434	.004	20	view →
PRAD	DFS	Median	All	0.833	0.931	<.001	20	view →
OV	DFS	Median	IV	0.226	0.389	.030	18	view →
STAD	DFS	Median	III,IV	0.476	0.671	.005	10	view →
MESO	DFS	Tertile	IV	0.286	0.773	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MUC20-OT1–HNSC (OS)

Open the HNSC breakdown →