MTUS1

Across TCGA patient cohorts, MTUS1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTUS1-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with MTUS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTUS1-to-partner and partner-to-MTUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MTUS1-low versus MTUS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTUS1→partner) and Y-score (partner→MTUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.345	+2.169	.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.181	-1.201	.020	.028	3	2
UCEC	ERK2 →	+0.170	+1.415	.004	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.169	-1.584	.001	.017	3	2
UCEC	Src_pY527 →	-0.323	-1.584	.015	.032	3	2
UCEC	Di-Ras3 →	-0.113	-2.102	.014	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eEF2 by MTUS1 expression — UCEC

Explore this box plot interactively →