MTUS1

Across TCGA cell cohorts, MTUS1 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTUS1-associated genes across cancer lineages are ACTL7A, OR12D2, and SMIM28. Each is linked with MTUS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTUS1-to-partner and partner-to-MTUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTL7A grouped by MTUS1-low versus MTUS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTUS1→partner) and Y-score (partner→MTUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACTL7A →	+0.019	+2.938	.002	.003	3	2
LARGE_INTESTINE	OR12D2 →	+0.047	+2.560	<.001	.008	3	2
CNS	SMIM28 →	+0.070	+5.321	<.001	.005	3	2
PANCREAS	OLIG3 →	+0.006	+5.000	<.001	.006	3	1
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
BLOOD_Myeloma	FRRS1L →	+0.040	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ACTL7A by MTUS1 expression — LARGE_INTESTINE

Explore this box plot interactively →