MTPN

Across TCGA patient cohorts, MTPN mutation is significantly associated with the RNA expression of many other genes, with 1,622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTPN-associated genes across cancer lineages are ATF4P2, RNA5SP55, and TRDV3. Each is linked with MTPN in more than 1 cancer types. Because this analysis shows association rather than direction, both MTPN-to-partner and partner-to-MTPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4P2 grouped by MTPN-low versus MTPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTPN→partner) and Y-score (partner→MTPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF4P2 →	+0.020	+2.014	.001	.006	3	2
COAD	RNA5SP55 →	+0.421	+4.790	<.001	.006	3	2
UCEC	TRDV3 →	+0.284	+1.662	<.001	.005	3	2
UCEC	HIGD1AP9 →	+0.235	+2.026	.005	<.001	3	2
UCEC	RPS10-NUDT3 →	+0.198	+1.839	.003	.006	3	1
UCEC	IGHV3OR16-6 →	+0.434	+2.034	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,622 associations by consensus.

ATF4P2 by MTPN expression — UCEC

Explore this box plot interactively →