MTPN

Across TCGA pan-cancer cohorts, MTPN RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated MTPN data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher MTPN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MTPN expression acts as an unfavorable survival marker, although some lineages such as KIRC and TGCT show a favorable association.

MESO, PAAD, and KIRC are the cancer types where MTPN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.287	0.433	.009	79	view →
PAAD	OS	Quartile	All	0.289	0.650	<.001	62	view →
KIRC	DFS	Tertile	All	0.854	0.657	<.001	60	view →
CESC	DFS	Tertile	III,IV	0.470	0.847	.007	58	view →
BLCA	DFS	Median	All	0.558	0.671	.001	49	view →
KIRP	OS	Median	II,III,IV	0.494	0.926	.005	44	view →
LIHC	DFS	Tertile	All	0.430	0.618	<.001	41	view →
KICH	OS	Quartile	All	0.600	1.000	.002	37	view →
ACC	DFS	Quartile	II,III,IV	0.315	0.768	.001	26	view →
LUAD	OS	Tertile	All	0.263	0.409	.003	19	view →
SCLC	DFS	Tertile	All	0.396	0.646	.015	18	view →
UVM	DFS	Quartile	II,III,IV	0.251	0.737	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

MTPN–MESO (DFS)

Open the MESO breakdown →