MTPN

Across TCGA pan-cancer cohorts, MTPN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MTPN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MTPN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTPN is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

KIRP, HNSC, and LIHC are the cancer types where MTPN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTPN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.825	<.001	11	view →
HNSC	All	II,III,IV	+0.587	<.001	10	view →
LIHC	Female	All	+0.907	<.001	9	view →
THCA	Male	III,IV	−0.839	<.001	9	view →
BLCA	Male	III,IV	+0.651	.005	6	view →
BRCA	All	II,III,IV	+0.316	<.001	6	view →
CHOL	Male	All	+2.198	<.001	5	view →
KIRC	Male	All	+0.363	<.001	5	view →
LUSC	Male	All	+0.366	<.001	4	view →
UCEC	All	All	−0.666	.005	2	view →
COAD	Male	II,III,IV	+0.315	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MTPN–KIRP

Open the KIRP breakdown →