MTPN

Across TCGA cell cohorts, MTPN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,831 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MTPN-associated GO terms across cancer lineages are Endoplasmic reticulum-plasma membrane tethering, Regulation of telomeric D-loop disassembly, and Positive regulation of isotype switching to IgG isotypes. Each is linked with MTPN in more than 12 cancer types. Because this analysis shows association rather than direction, both MTPN-to-partner and partner-to-MTPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum-plasma membrane tethering grouped by MTPN-low versus MTPN-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTPN→partner) and Y-score (partner→MTPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Endoplasmic reticulum-plasma membrane tethering →	+0.182	+1.014	<.001	<.001	3	13
CNS	Regulation of telomeric D-loop disassembly →	+0.097	+0.859	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.135	+0.650	<.001	.002	3	12
OVARY	Regulation of membrane tubulation →	+0.140	+0.856	.001	<.001	3	11
LUNG_SCLC	Positive regulation of viral transcription →	+0.119	+0.401	.001	.001	3	11
SKIN	Phosphatidylinositol biosynthetic process →	+0.046	+0.681	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,831 associations by consensus.

Endoplasmic reticulum-plasma membrane tethering by MTPN expression — BREAST

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