MTNR1A

Across TCGA cell cohorts, MTNR1A mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTNR1A-associated genes across cancer lineages are BPIFB6, TFDP3, and C14orf180. Each is linked with MTNR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MTNR1A-to-partner and partner-to-MTNR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by MTNR1A-low versus MTNR1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTNR1A→partner) and Y-score (partner→MTNR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TFDP3 →	+0.031	+3.196	<.001	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.102	+3.155	.002	.008	3	1
LARGE_INTESTINE	CENPVL1 →	+0.150	+3.510	<.001	.003	3	1
LARGE_INTESTINE	INSRR →	+0.031	+3.584	<.001	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.281	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

BPIFB6 by MTNR1A expression — LARGE_INTESTINE

Explore this box plot interactively →