MTNR1A

Across TCGA pan-cancer cohorts, MTNR1A RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated MTNR1A data layer compared with 4 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MTNR1A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MTNR1A expression acts as an unfavorable survival marker, although some lineages such as BRCA and READ show a favorable association.

BRCA, CESC, and ACC are the cancer types where MTNR1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	All	0.976	0.936	.006	37	view →
CESC	OS	Median	All	0.833	0.909	.004	32	view →
ACC	DFS	Tertile	All	0.098	0.483	.020	30	view →
BLCA	DFS	Quartile	All	0.127	0.438	<.001	29	view →
UCEC	DFS	Median	All	0.581	0.682	.012	22	view →
READ	OS	Tertile	III,IV	1.000	0.790	.005	22	view →
LUSC	OS	Tertile	III,IV	0.191	0.466	.002	22	view →
MESO	OS	Tertile	II,III,IV	0.301	0.442	.039	18	view →
PRAD	DFS	Median	All	0.919	0.852	.012	14	view →
ESCA	DFS	Median	II,III,IV	0.433	0.273	.019	8	view →
LIHC	OS	Quartile	All	0.387	0.596	.032	5	view →
SCLC	DFS	Median	All	0.420	0.197	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

MTNR1A–BRCA (DFS)

Open the BRCA breakdown →