Across TCGA pan-cancer cohorts, MTND4P28 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MTND4P28’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MTND4P28 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTND4P28 is over-expressed in tumor.
LUSC are the cancer types where MTND4P28 tumor–normal differential expression is most reproducible.