Q-omics provides the consensus-scored MTAPP1 profile across patient tissues and cancer cell-line models. MTAPP1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, MTAPP1 is differentially expressed in 7, with the highest sampling consensus in LUAD. Additionally, MTAPP1 RNA expression shows 9,506 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UCEC, LUAD, and THYM as cancer lineages where MTAPP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MTAPP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MTAPP1 survival associations across molecular data types. MTAPP1 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MTAPP1 RNA expression–survival associations across cancer types. High MTAPP1 expression shows unfavorable associations in UCEC, COAD, THCA, LGG and SARC, but favorable associations in CESC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for MTAPP1 RNA expression.
This table summarizes MTAPP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for MTAPP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MTAPP1 shows lower tumor expression in LUAD, LUSC, KICH and THCA and higher tumor expression in HNSC and CHOL. The LUAD box plot shows higher MTAPP1 RNA expression in normal versus tumor tissue (log2 FC = −0.209, t-test p = .001).
This table shows molecular features associated with MTAPP1 in patient tissues and cancer cell lines. In patient samples, MTAPP1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
