MT4

Across TCGA patient cohorts, MT4 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MT4-associated genes across cancer lineages are MIR4311, RNA5SP415, and RNU6-486P. Each is linked with MT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MT4-to-partner and partner-to-MT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4311 grouped by MT4-low versus MT4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT4→partner) and Y-score (partner→MT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4311 →	+0.315	+4.302	<.001	.007	3	2
UCEC	RNA5SP415 →	+0.951	+3.488	<.001	.008	3	2
SKCM	RNU6-486P →	+0.201	+5.488	<.001	.001	3	2
UCEC	MIR6515 →	+0.436	+4.335	<.001	.007	3	1
SKCM	LINC01217 →	+0.042	+4.147	<.001	.008	3	1
SKCM	RNA5SP33 →	+0.434	+3.211	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

MIR4311 by MT4 expression — SKCM

Explore this box plot interactively →