MT4

Across TCGA pan-cancer cohorts, MT4 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated MT4 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MT4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MT4 expression acts as an unfavorable survival marker, although some lineages such as STAD and ESCA show a favorable association.

ACC, LUAD, and STAD are the cancer types where MT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.232	0.804	<.001	75	view →
LUAD	DFS	Tertile	All	0.321	0.815	<.001	54	view →
STAD	OS	Tertile	III,IV	0.706	0.281	.012	48	view →
LUSC	OS	Tertile	II,III,IV	0.405	0.807	.003	30	view →
HNSC	DFS	Quartile	III,IV	0.108	0.417	.002	26	view →
SKCM	OS	Tertile	All	0.646	0.797	.002	24	view →
PCPG	DFS	Tertile	All	0.104	0.904	<.001	18	view →
BLCA	DFS	Tertile	II,III,IV	0.376	0.530	.020	15	view →
LIHC	DFS	Tertile	III,IV	0.136	0.348	.019	9	view →
ESCA	OS	Tertile	III,IV	0.726	0.488	.041	6	view →
TGCT	DFS	Tertile	All	0.916	0.730	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

MT4–ACC (DFS)

Open the ACC breakdown →