MT4

Across TCGA pan-cancer cohorts, MT4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MT4’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where MT4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MT4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

UCEC and THCA are the cancer types where MT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	+1.443	.032	2	view →
THCA	Female	All	−0.025	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

MT4–UCEC

Open the UCEC breakdown →