MT4

Across TCGA cell cohorts, MT4 RNA expression is significantly associated with the mutation status of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MT4-associated genes across cancer lineages are NPAP1, PRRC2A, and TANC2. Each is linked with MT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MT4-to-partner and partner-to-MT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1 grouped by MT4-low versus MT4-high in LUNG_NSCLC_LUSC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT4→partner) and Y-score (partner→MT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NPAP1 →	+3.000	+0.871	.006	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PRRC2A →	+4.510	+0.662	.003	<.001	3	1
LARGE_INTESTINE	TANC2 →	+2.649	+2.765	.001	<.001	3	1
LARGE_INTESTINE	NFIX →	+3.556	+3.996	.007	<.001	3	1
LARGE_INTESTINE	TRPV1 →	+2.234	+1.583	.003	.001	3	1
LARGE_INTESTINE	TCTN1 →	+3.556	+3.277	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

NPAP1 by MT4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →