MT1L

Across TCGA patient cohorts, MT1L mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MT1L-associated genes across cancer lineages are RN7SL387P, PSMD7P1, and MICOS10-NBL1. Each is linked with MT1L in more than 1 cancer types. Because this analysis shows association rather than direction, both MT1L-to-partner and partner-to-MT1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL387P grouped by MT1L-low versus MT1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT1L→partner) and Y-score (partner→MT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL387P →	+0.252	+3.496	.003	.005	3	1
UCEC	PSMD7P1 →	+0.296	+3.713	.006	.007	3	1
UCEC	MICOS10-NBL1 →	+0.082	+3.694	.002	.007	3	1
UCEC	MIR6768 →	+0.937	+3.690	.005	.007	3	1
UCEC	RN7SL197P →	+0.281	+3.599	<.001	.007	3	1
UCEC	H3P46 →	+0.184	+4.877	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

RN7SL387P by MT1L expression — UCEC

Explore this box plot interactively →