MT1L

Across TCGA pan-cancer cohorts, MT1L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MT1L data layer compared with 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher MT1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MT1L expression acts as an unfavorable survival marker, although some lineages such as UCEC and THCA show a favorable association.

LUSC, PAAD, and LGG are the cancer types where MT1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.551	0.726	<.001	78	view →
PAAD	DFS	Tertile	All	0.351	0.580	<.001	67	view →
LGG	OS	Median	All	0.748	0.871	<.001	48	view →
CESC	DFS	Tertile	III,IV	0.455	0.826	.001	48	view →
UCEC	OS	Quartile	All	0.888	0.578	<.001	44	view →
UCS	OS	Tertile	IV	0.141	0.821	.010	42	view →
HNSC	DFS	Tertile	All	0.620	0.745	.003	32	view →
BLCA	OS	Tertile	All	0.547	0.792	.003	22	view →
COAD	OS	Quartile	All	0.681	0.903	.011	22	view →
KIRC	DFS	Median	II,III,IV	0.733	0.859	.013	19	view →
THCA	DFS	Tertile	All	0.888	0.748	.005	19	view →
KIRP	DFS	Tertile	IV	0.038	0.765	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MT1L–LUSC (DFS)

Open the LUSC breakdown →