Across TCGA pan-cancer cohorts, MT-TN RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MT-TN’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MT-TN RNA is repressed in tumor relative to normal tissue. In most cancer types MT-TN is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and KICH are the cancer types where MT-TN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MT-TN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.288	.012	4	view →
HNSC	All	II,III,IV	−0.196	.017	2	view →
KICH	All	All	+0.296	.014	1	view →
LIHC	Male	All	−0.193	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MT-TN RNA expression & survival · all MT-TN data types