Across TCGA pan-cancer cohorts, MT-TA RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated MT-TA data layer.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MT-TA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MT-TA expression acts as an unfavorable survival marker, although some lineages such as KICH and LGG show a favorable association.
HNSC, DLBC, and LUSC are the cancer types where MT-TA RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.