Across TCGA cell cohorts, MT-CYB mutation is significantly associated with the RNA expression of many other genes, with 821 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MT-CYB-associated genes across cancer lineages are HBG1, FAM43A, and GP5. Each is linked with MT-CYB in more than 3 cancer types. Because this analysis shows association rather than direction, both MT-CYB-to-partner and partner-to-MT-CYB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-CYB→partner) and Y-score (partner→MT-CYB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HBG1 →	+0.126	+3.675	<.001	.003	3	3
LUNG_SCLC	FAM43A →	+1.198	+1.700	.001	.005	3	3
BREAST	GP5 →	+0.027	+2.333	<.001	.002	3	3
SKIN	STX5 →	+0.506	+3.137	.008	.007	3	3
BLOOD_Leukemia	ARRDC1 →	+0.793	+3.351	.005	.003	3	3
STOMACH	B3GNT3 →	+1.935	+2.070	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 821 associations by consensus.

Exploration

MT-CYB survival (RNA) · tumor vs normal (RNA) · all MT-CYB data types