Across TCGA patient cohorts, MT-CO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,406 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MT-CO1-associated proteins across cancer lineages are LRPPRC, MCCC2, and TUFM. Each is linked with MT-CO1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MT-CO1-to-partner and partner-to-MT-CO1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-CO1→partner) and Y-score (partner→MT-CO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LRPPRC →	+0.490	+0.503	<.001	<.001	3	7
BRCA	MCCC2 →	+0.587	+0.511	.002	.003	3	7
COAD	TUFM →	+0.342	+0.622	<.001	.002	3	6
LSCC	SLIRP →	+0.470	+0.379	<.001	<.001	3	6
GBM	IARS2 →	+0.348	+0.575	<.001	<.001	3	6
PDAC	MDH2 →	+0.440	+0.612	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,406 associations by consensus.

Exploration

MT-CO1 survival (RNA) · tumor vs normal (RNA) · all MT-CO1 data types