Across TCGA cell cohorts, MT-ATP6 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MT-ATP6-associated genes across cancer lineages are SCN7A, DAZ1, and PRL. Each is linked with MT-ATP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MT-ATP6-to-partner and partner-to-MT-ATP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MT-ATP6→partner) and Y-score (partner→MT-ATP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCN7A →	+0.352	+3.612	.001	.004	3	2
OVARY	DAZ1 →	+0.115	+3.736	<.001	.007	3	2
BREAST	PRL →	+0.068	+3.758	.003	.007	3	2
LUNG_SCLC	NUP210L →	+0.084	+2.125	.001	.002	3	2
SOFT_TISSUE	OR11H6 →	+0.039	+5.515	<.001	<.001	3	1
LUNG_NSCLC_LUAD	CDH9 →	+0.092	+3.450	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

MT-ATP6 survival (RNA) · tumor vs normal (RNA) · all MT-ATP6 data types