MST1R

Across TCGA patient cohorts, MST1R mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MST1R-associated genes across cancer lineages are Smad4, eIF4E, and p27_pT198. Each is linked with MST1R in more than 3 cancer types. Because this analysis shows association rather than direction, both MST1R-to-partner and partner-to-MST1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by MST1R-low versus MST1R-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MST1R→partner) and Y-score (partner→MST1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smad4 →	+0.175	+3.807	<.001	<.001	3	4
UCEC	eIF4E →	+0.190	+2.058	.004	<.001	3	3
UCEC	p27_pT198 →	+0.101	+1.807	.003	.024	3	3
UCEC	Rictor_pT1135 →	-0.099	-2.502	.002	.001	3	3
UCEC	Shc_pY317 →	-0.117	-1.584	.015	.017	3	3
UCEC	Caspase-7-cleavedD198 →	+0.700	+2.019	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Smad4 by MST1R expression — SKCM

Explore this box plot interactively →