MSN

Across TCGA patient cohorts, MSN mutation is significantly associated with the RNA expression of many other genes, with 2,216 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSN-associated genes across cancer lineages are RPL22P5, HNRNPMP2, and OR51A8P. Each is linked with MSN in more than 2 cancer types. Because this analysis shows association rather than direction, both MSN-to-partner and partner-to-MSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL22P5 grouped by MSN-low versus MSN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSN→partner) and Y-score (partner→MSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPL22P5 →	+0.080	+3.366	<.001	.006	3	3
COAD	HNRNPMP2 →	+0.046	+4.602	<.001	.003	3	3
BRCA	OR51A8P →	+0.055	+4.866	<.001	.003	3	3
LUAD	HMGN2P22 →	+0.439	+4.191	<.001	.004	3	3
UCEC	GPATCH3 →	+0.265	+2.023	.002	<.001	3	3
CESC	TLE7 →	+0.075	+3.273	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,216 associations by consensus.

RPL22P5 by MSN expression — CESC

Explore this box plot interactively →