MSN

Across TCGA pan-cancer cohorts, MSN RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MSN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MSN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MSN is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where MSN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MSN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.578	<.001	12	view →
THCA	Male	All	+1.072	<.001	10	view →
KIRC	Female	All	+0.798	<.001	10	view →
KICH	Female	II,III,IV	−2.102	<.001	8	view →
LUAD	Male	All	−0.791	<.001	8	view →
LIHC	All	All	+0.805	<.001	7	view →
LUSC	Female	All	−0.961	<.001	6	view →
BRCA	All	All	−0.385	<.001	6	view →
CHOL	All	All	+2.000	.001	5	view →
KIRP	All	II,III,IV	+0.526	.010	4	view →
BLCA	Male	All	−1.073	.014	3	view →
UCEC	All	All	−1.163	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MSN–HNSC

Open the HNSC breakdown →