MSLNL

Across TCGA cell cohorts, MSLNL mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible MSLNL-associated genes across cancer lineages are OR7E24, KRTAP5-4, and EPPIN. Each is linked with MSLNL in more than 1 cancer types. Because this analysis shows association rather than direction, both MSLNL-to-partner and partner-to-MSLNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E24 grouped by MSLNL-low versus MSLNL-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSLNL→partner) and Y-score (partner→MSLNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR7E24 →	+0.022	+4.369	<.001	.008	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.024	+4.369	<.001	.008	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR3A1 →	+1.055	+4.922	<.001	.009	3	1
BLOOD_Leukemia	FIGLA →	+0.036	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	OR1D4 →	+0.052	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR7E24 by MSLNL expression — SOFT_TISSUE

Explore this box plot interactively →