MSH3

Across TCGA patient cohorts, MSH3 mutation is significantly associated with the RNA expression of many other genes, with 4,548 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSH3-associated genes across cancer lineages are MIR138-1, H2AB2, and RNU6-362P. Each is linked with MSH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSH3-to-partner and partner-to-MSH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR138-1 grouped by MSH3-low versus MSH3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH3→partner) and Y-score (partner→MSH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR138-1 →	+0.341	+3.432	.001	.009	3	3
BRCA	H2AB2 →	+0.053	+7.057	<.001	.009	3	2
CESC	RNU6-362P →	+0.446	+7.584	<.001	<.001	3	2
UCEC	DESI1 →	+0.384	+2.169	<.001	<.001	3	2
UCEC	RBFA →	+0.326	+1.436	.003	.006	3	2
UCEC	GARS1 →	+0.527	+1.914	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,548 associations by consensus.

MIR138-1 by MSH3 expression — BLCA

Explore this box plot interactively →