MSH3

Across TCGA pan-cancer cohorts, MSH3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MSH3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MSH3 RNA is repressed in tumor relative to normal tissue. In most cancer types MSH3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and LUAD are the cancer types where MSH3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MSH3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.450	<.001	7	view →
LIHC	All	All	+0.499	<.001	5	view →
LUAD	Male	All	+0.474	<.001	5	view →
KICH	All	All	−0.746	<.001	4	view →
READ	All	III,IV	+0.714	.011	3	view →
KIRP	Male	All	−0.557	<.001	3	view →
PRAD	All	All	+0.273	.014	2	view →
LUSC	Male	All	+0.222	.023	2	view →
CHOL	All	All	+0.581	.021	1	view →
ESCA	Female	All	+0.496	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

MSH3–THCA

Open the THCA breakdown →