Q-omics provides the consensus-scored MSH2-OT1 profile across patient tissues and cancer cell-line models. MSH2-OT1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, MSH2-OT1 is differentially expressed in 8, with the highest sampling consensus in THCA. Additionally, MSH2-OT1 RNA expression shows 18,007 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UCEC, THCA, and TGCT as cancer lineages where MSH2-OT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MSH2-OT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MSH2-OT1 survival associations across molecular data types. MSH2-OT1 RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MSH2-OT1 RNA expression–survival associations across cancer types. High MSH2-OT1 expression shows unfavorable associations in UCEC, KIRP and ACC, but favorable associations in PAAD, LGG and KIRC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for MSH2-OT1 RNA expression.
This table summarizes MSH2-OT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for MSH2-OT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MSH2-OT1 shows lower tumor expression in THCA, BRCA, KICH and COAD and higher tumor expression in LIHC and LUSC. The THCA box plot shows higher MSH2-OT1 RNA expression in normal versus tumor tissue (log2 FC = −0.479, t-test p < 0.001).
This table shows molecular features associated with MSH2-OT1 in patient tissues and cancer cell lines. In patient samples, MSH2-OT1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
