MSH2-OT1

Across TCGA pan-cancer cohorts, MSH2-OT1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MSH2-OT1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MSH2-OT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MSH2-OT1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LGG show a favorable association.

UCEC, PAAD, and KIRP are the cancer types where MSH2-OT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.561	0.739	<.001	96	view →
PAAD	OS	Quartile	All	0.567	0.237	<.001	39	view →
KIRP	OS	Quartile	III,IV	0.192	0.546	.006	27	view →
ACC	DFS	Median	All	0.335	0.559	.034	26	view →
LGG	OS	Quartile	All	0.941	0.794	.002	25	view →
KIRC	OS	Tertile	All	0.927	0.859	.004	23	view →
BLCA	OS	Tertile	IV	0.284	0.681	.003	21	view →
SKCM	OS	Median	All	0.911	0.832	.004	19	view →
UVM	OS	Tertile	II,III,IV	1.000	0.413	.007	18	view →
BRCA	OS	Median	II,III,IV	0.934	0.888	.017	15	view →
LUAD	DFS	Tertile	All	0.853	0.657	<.001	15	view →
LAML	DFS	Median	All	0.535	0.389	.030	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MSH2-OT1–UCEC (DFS)

Open the UCEC breakdown →