MS4A8

Across TCGA cell cohorts, MS4A8 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MS4A8-associated genes across cancer lineages are PDE6H, CELA1, and EPPIN. Each is linked with MS4A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A8-to-partner and partner-to-MS4A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE6H grouped by MS4A8-low versus MS4A8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A8→partner) and Y-score (partner→MS4A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PDE6H →	+0.173	+3.951	<.001	.005	3	1
LUNG_NSCLC_LUAD	CELA1 →	+0.147	+4.273	<.001	.002	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	ACTRT1 →	+0.038	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TRIM42 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.113	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PDE6H by MS4A8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →