MS4A8

Across TCGA pan-cancer cohorts, MS4A8 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MS4A8’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MS4A8 RNA is repressed in tumor relative to normal tissue. In most cancer types MS4A8 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and COAD are the cancer types where MS4A8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MS4A8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−3.634	<.001	8	view →
LUAD	Female	All	−2.351	<.001	7	view →
COAD	Female	All	−2.206	<.001	7	view →
BRCA	All	II,III,IV	+0.683	<.001	6	view →
PAAD	All	All	+2.335	.008	4	view →
KICH	All	All	−0.060	.001	4	view →
UCEC	All	All	−2.126	.005	2	view →
PRAD	All	All	+1.498	<.001	2	view →
THCA	All	All	+0.072	.023	2	view →
STAD	Male	IV	−1.835	.023	1	view →
HNSC	All	All	−0.576	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MS4A8–LUSC

Open the LUSC breakdown →