MS4A6E

Across TCGA cell cohorts, MS4A6E mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MS4A6E-associated genes across cancer lineages are FAM205C, TRIM64B, and SLC22A6. Each is linked with MS4A6E in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A6E-to-partner and partner-to-MS4A6E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205C grouped by MS4A6E-low versus MS4A6E-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A6E→partner) and Y-score (partner→MS4A6E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM205C →	+0.088	+5.029	<.001	.006	3	1
LUNG_SCLC	TRIM64B →	+0.066	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	SLC22A6 →	+0.006	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FAM205C by MS4A6E expression — LUNG_SCLC

Explore this box plot interactively →