MS4A6E

Across TCGA pan-cancer cohorts, MS4A6E RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated MS4A6E data layer compared with 4 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MS4A6E RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MS4A6E expression acts as an unfavorable survival marker, although some lineages such as PAAD and BRCA show a favorable association.

ACC, PAAD, and BRCA are the cancer types where MS4A6E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Quartile	All	0.213	0.714	<.001	61	view →
PAAD	DFS	Tertile	II,III,IV	0.446	0.231	.007	42	view →
BRCA	OS	Tertile	All	0.976	0.954	.017	22	view →
MESO	OS	Median	II,III,IV	0.703	0.455	.005	19	view →
PCPG	OS	Quartile	All	0.784	1.000	.011	15	view →
UCEC	DFS	Tertile	All	0.770	0.853	.019	12	view →
STAD	OS	Quartile	All	0.540	0.760	.012	12	view →
GBM	DFS	Quartile	All	0.169	0.383	.013	6	view →
LUAD	DFS	Quartile	IV	0.333	0.774	.045	6	view →
LGG	DFS	Tertile	All	0.798	0.687	.032	4	view →
LUSC	OS	Quartile	All	0.726	0.816	.026	4	view →
ESCA	OS	Quartile	III,IV	0.796	0.425	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

MS4A6E–ACC (OS)

Open the ACC breakdown →