MRPS34

Across TCGA cell cohorts, MRPS34 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,442 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MRPS34-associated GO terms across cancer lineages are rRNA pseudouridine synthesis, Enzyme-directed rRNA pseudouridine synthesis, and Peptidyl-methionine modification. Each is linked with MRPS34 in more than 14 cancer types. Because this analysis shows association rather than direction, both MRPS34-to-partner and partner-to-MRPS34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA pseudouridine synthesis grouped by MRPS34-low versus MRPS34-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS34→partner) and Y-score (partner→MRPS34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	rRNA pseudouridine synthesis →	+0.120	+0.594	<.001	<.001	3	15
LUNG_SCLC	Enzyme-directed rRNA pseudouridine synthesis →	+0.148	+0.853	<.001	<.001	3	15
OESOPHAGUS	Peptidyl-methionine modification →	+0.235	+0.768	<.001	<.001	3	14
URINARY_TRACT	Termination of RNA polymerase III transcription →	+0.115	+0.666	.007	.007	3	14
BREAST	Pyrimidine deoxyribonucleoside triphosphate metabolic process →	+0.147	+0.708	<.001	<.001	3	13
LIVER	rRNA 5'-end processing →	+0.161	+0.761	.004	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,442 associations by consensus.

rRNA pseudouridine synthesis by MRPS34 expression — BONE

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