MRPS34

Across TCGA pan-cancer cohorts, MRPS34 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MRPS34 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MRPS34 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPS34 expression acts as an unfavorable survival marker, although some lineages such as STAD and OV show a favorable association.

UVM, UCS, and LUAD are the cancer types where MRPS34 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.419	0.734	<.001	124	view →
UCS	OS	Tertile	III,IV	0.382	0.780	.007	50	view →
LUAD	DFS	Tertile	II,III,IV	0.458	0.642	.005	44	view →
STAD	DFS	Quartile	II,III,IV	0.703	0.463	.001	43	view →
ACC	OS	Median	II,III,IV	0.745	0.951	<.001	43	view →
LIHC	DFS	Quartile	All	0.322	0.535	<.001	37	view →
LAML	DFS	Median	All	0.410	0.702	.003	26	view →
KIRP	DFS	Quartile	All	0.869	0.985	.004	20	view →
LGG	OS	Tertile	All	0.712	0.866	.004	18	view →
CHOL	DFS	Median	All	0.185	0.632	.006	15	view →
OV	DFS	Quartile	IV	0.610	0.346	.026	14	view →
SCLC	OS	Quartile	All	0.533	0.283	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MRPS34–UVM (DFS)

Open the UVM breakdown →