MRPS34

Across TCGA pan-cancer cohorts, MRPS34 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MRPS34’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MRPS34 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPS34 is over-expressed in tumor.

HNSC, KIRC, and COAD are the cancer types where MRPS34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.756	<.001	12	view →
KIRC	All	IV	+0.714	<.001	12	view →
COAD	Female	All	+1.287	<.001	11	view →
KIRP	Male	II,III,IV	+0.917	<.001	11	view →
BLCA	All	III,IV	+0.754	<.001	10	view →
LIHC	Female	II,III,IV	+1.005	<.001	9	view →
LUSC	Female	All	+0.980	<.001	8	view →
STAD	All	II,III,IV	+0.808	<.001	8	view →
LUAD	Female	III,IV	+1.014	<.001	7	view →
BRCA	All	III,IV	+1.206	<.001	6	view →
UCEC	All	All	+0.696	<.001	6	view →
CHOL	All	All	+1.666	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MRPS34–HNSC

Open the HNSC breakdown →