MRPS33

Across TCGA patient cohorts, MRPS33 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS33-associated genes across cancer lineages are CLPTM1LP1, RNA5SP414, and RNA5SP411. Each is linked with MRPS33 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS33-to-partner and partner-to-MRPS33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPTM1LP1 grouped by MRPS33-low versus MRPS33-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS33→partner) and Y-score (partner→MRPS33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLPTM1LP1 →	+0.064	+7.731	<.001	.009	3	1
UCEC	RNA5SP414 →	+1.338	+3.670	<.001	.002	3	1
UCEC	RNA5SP411 →	+2.571	+3.715	<.001	.001	3	1
UCEC	RNA5SP412 →	+1.163	+3.382	<.001	.004	3	1
BRCA	MIR551B →	+0.276	+7.731	<.001	.009	3	1
UCEC	MIR378E →	+0.675	+5.038	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

CLPTM1LP1 by MRPS33 expression — BRCA

Explore this box plot interactively →