MRPS33

Across TCGA pan-cancer cohorts, MRPS33 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MRPS33 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher MRPS33 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS33 expression acts as an unfavorable survival marker, although some lineages such as OV and BLCA show a favorable association.

OV, KICH, and CESC are the cancer types where MRPS33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	IV	0.608	0.310	<.001	90	view →
KICH	DFS	Tertile	All	0.540	0.960	<.001	65	view →
CESC	DFS	Median	IV	0.206	0.765	<.001	54	view →
UCS	OS	Tertile	All	0.186	0.459	.022	26	view →
BLCA	DFS	Quartile	III,IV	0.660	0.343	.005	25	view →
LIHC	OS	Quartile	All	0.667	0.875	.003	22	view →
SCLC	OS	Median	All	0.595	0.796	.002	18	view →
LUSC	OS	Tertile	All	0.823	0.715	.002	15	view →
GBM	OS	Tertile	All	0.347	0.520	.006	14	view →
UVM	DFS	Median	III,IV	0.509	0.797	.026	9	view →
HNSC	DFS	Tertile	All	0.264	0.385	.024	8	view →
ACC	OS	Quartile	III,IV	1.000	0.279	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MRPS33–OV (DFS)

Open the OV breakdown →