MRPS31

Across TCGA patient cohorts, MRPS31 mutation is significantly associated with the RNA expression of many other genes, with 2,987 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS31-associated genes across cancer lineages are MIR548Y, RN7SKP135, and DEFB117. Each is linked with MRPS31 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRPS31-to-partner and partner-to-MRPS31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548Y grouped by MRPS31-low versus MRPS31-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS31→partner) and Y-score (partner→MRPS31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR548Y →	+0.476	+5.435	<.001	<.001	3	3
BRCA	RN7SKP135 →	+0.098	+7.731	<.001	.009	3	2
LUAD	DEFB117 →	+0.646	+4.303	<.001	.009	3	2
UCEC	RNU4-58P →	+0.166	+2.133	.002	.007	3	2
UCEC	RNA5SP89 →	+0.100	+3.002	.005	.006	3	2
UCEC	BMS1P13 →	+0.036	+1.936	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,987 associations by consensus.

MIR548Y by MRPS31 expression — BLCA

Explore this box plot interactively →