mitochondrial ribosomal protein L53 pseudogene 1Genealiases: []
Q-omics provides the consensus-scored MRPL53P1 profile across patient tissues and cancer cell-line models. MRPL53P1 expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, MRPL53P1 is differentially expressed in 4, with the highest sampling consensus in HNSC. Additionally, MRPL53P1 RNA expression shows 11,842 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight SKCM, HNSC, and UVM as cancer lineages where MRPL53P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MRPL53P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MRPL53P1 survival associations across molecular data types. MRPL53P1 RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MRPL53P1 RNA expression–survival associations across cancer types. High MRPL53P1 expression shows unfavorable associations in THCA, UVM, KIRC, OV and LUAD, but favorable associations in SKCM. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for MRPL53P1 RNA expression.
This table summarizes MRPL53P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MRPL53P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MRPL53P1 shows lower tumor expression in LUAD and STAD and higher tumor expression in HNSC, STAD and KIRC. The HNSC box plot shows higher MRPL53P1 RNA expression in tumor versus normal tissue (log2 FC = +0.113, t-test p = .004).
This table shows molecular features associated with MRPL53P1 in patient tissues and cancer cell lines. In patient samples, MRPL53P1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
