MRPL53P1

Across TCGA pan-cancer cohorts, MRPL53P1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MRPL53P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MRPL53P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPL53P1 is over-expressed in tumor, although a few such as LUAD and STAD show the opposite, repressed pattern.

HNSC, STAD, and LUAD are the cancer types where MRPL53P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL53P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.113	.004	6	view →
STAD	All	II,III,IV	+0.525	.012	4	view →
LUAD	Male	III,IV	−0.438	.030	1	view →
STAD	Male	IV	−0.435	.041	1	view →
KIRC	Male	IV	+0.112	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 4 lineages.

MRPL53P1–HNSC

Open the HNSC breakdown →