MRPL41

Across TCGA patient cohorts, MRPL41 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible MRPL41-associated genes across cancer lineages are RNU7-176P, RNU1-76P, and RNU6-179P. Each is linked with MRPL41 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL41-to-partner and partner-to-MRPL41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-176P grouped by MRPL41-low versus MRPL41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL41→partner) and Y-score (partner→MRPL41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU7-176P →	+0.975	+5.299	<.001	.006	3	2
HNSC	RNU1-76P →	+0.158	+7.954	<.001	.008	3	1
BLCA	RNU6-179P →	+0.308	+5.444	<.001	.002	3	1
BLCA	RNU6-1316P →	+0.422	+5.064	<.001	.001	3	1
BLCA	RNA5SP91 →	+0.409	+4.840	<.001	.002	3	1
HNSC	LONRF2P2 →	+0.049	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

RNU7-176P by MRPL41 expression — UCEC

Explore this box plot interactively →